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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Transplantation. 2015 Aug;99(8):1553–1559. doi: 10.1097/TP.0000000000000813

Figure 1. “Trogocytosis” as a mechanism for suppression mediated by double-negative T cells.

Figure 1

MHC-alloantigen complex on antigen presenting cells (APC) engages the T cell receptor (TCR) on double-negative (DN) Tregs. This is followed by release of MHC/antigen complex by the APC and capture of the MHC/antigen complex by the DN Treg which integrates the complex into its cell membrane. The DN Tregs express this captured MHC/antigen complex on their cell surface. CD8+ T cells bearing the cognate TCR engage the MHC/antigen complex on the DN Tregs. DN Tregs then transmit an apoptotic signal via FasL on the DN Tregs through the Fas receptor on CD8+ T cells. The CD8+ effector T cells undergo apoptosis and are deleted.