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| Treg Population | Contact-Dependent | Contact-Independent | Other |
|---|---|---|---|
| CD8+ Tregs | Perforin | IDO | Promotes generation of CD4+CD25+ Tregs |
| FasL/Fas | IFN-γ | ||
| Fibroleukin-2 (Fgl-2) | |||
| TGF-β | |||
| DN Tregs | Perforin | None reported | Down-regulate costimulatory molecules on APCs |
| FasL/Fas | |||
| Tr1 Tregs | Perforin | IL-10 |
