. Author manuscript; available in PMC: 2016 Sep 1.

Published in final edited form as: Arthritis Rheumatol. 2015 Sep;67(9):2292–2302. doi: 10.1002/art.39245

Table 2.

ABIN1 Summary.

Function	Mechanism	Phenotypic Associations	References
Inhibition of NF-κB	Inhibits by an A20 dependent and/or A20 independent mechanism ^* (See Figure 2)	Lupus-like inflammatory disease Psoriasis Glomerular nephritis	5, 6, 7, 9, 14, 41
Inhibition of MAPKs (JNK, ERK, and p38α)	Inhibits TLR dependent MAPK activity^* Suppresses ERK2 nuclear translocation	Lupus-like inflammatory disease Psoriasis	5, 41, 47
Inhibition of C/EBPβ	Inhibits TLR dependent C/EBPβ activity	Lupus-like inflammatory disease	37
Prevention of apoptosis	Inhibits caspase 8/FADD interaction upon TNFα stimulation^*	Embryonic development	13

Requires polyubiquitin binding function