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. Author manuscript; available in PMC: 2016 Aug 26.
Published in final edited form as: Adv Healthc Mater. 2015 Jun 23;4(12):1813–1818. doi: 10.1002/adhm.201500307

Figure 1.

Figure 1

Cumulative release of selenite ions and therapeutic effect of HANSe treatment on aggressive osteosarcoma. a) HANSe3 exhibits a sustained release profile compared to HANSe10. All experiments are repeated at least three times. b) Plot of tumor volume versus time. Mice bearing osteosarcoma are euthanized at each predetermined time point, and no mice die from tumor. Data are presented as mean tumor volume ± standard deviation (n=3). Tumors in the HANSe3 group are significantly smaller than all other groups from day 15 to day 23 (* indicates p<0.05 for HANSe3 and ** indicates p<0.01 for HANSe3, versus no treatment control, HANSe10, and HAN groups by SPSS with Tukey’s multiple comparison tests). c) Gross view of representative tumor-bearing mice after treatments for 30 days. Green arrows highlight the remaining dense materials.