Table 2.

Univariate and multivariable analysis of prognostic indicators on overall survival and cancer-specific survival for 1095 colorectal cancer patients

Parameters	Overall survival				Cancer-specific survival
	Univariate analysis		Multivariable analysis		Univariate analysis		Multivariable analysis
	HRd (95 % CIe)	P value	HRd (95 % CIe)	P value	HRd (95 % CIe)	P value	HRd (95 % CIe)	P value
Age (years)	1.352 (1.099 – 1.664)	0.002*	1.347 (1.008 – 1.801)	0.044*	1.349 (1.096 – 1.601)	0.005*	1.362 (1.018 – 1.822)	0.037*
≥65 vs <65 (576/519)
Gender	1.098 (0.893 – 1.349)	0.377	1.036 (0.795 – 1.506)	0.792	1.096 (0.891 – 1.347)	0.386	1.032 (0.792 – 1.345)	0.817
Male vs Female (619/476)
Location	1.309 (1.041 – 1.647)	0.021*	1.172 (0.870 – 1.580)	0.296	1.303 (1.036 – 1.639)	0.024*	1.168 (0.867 – 1.572)	0.308
Right vs Left (249/846)
Tumor size	1.477 (1.200 – 1.817)	<0.001*	0.981 (0.745 – 1.292)	0.893	1.480 (1.203 – 1.821)	<0.001*	0.979 (0.744 – 1.289)	0.880
≥5 cm vs <5 cm (466/612)
Tumor depth	2.959 (2.088 – 4.193)	<0.001*	1.385 (0.596 – 3.220)	0.449	2.867 (2.094 – 4.205)	<0.001*	1.379 (0.593 – 3.205)	0.455
T3 + T4 vs T1 + T2 (853/235)
Lymph Node metastasis	2.464 (1.996 – 3.042)	<0.001*	1.055 (0.644 – 1.730)	0.831	2.460 (1.992 – 3.037)	<0.001*	1.060 (0.647 – 1.738)	0.816
Yes vs No (452/633)
AJCCa stage	3.441 (2.753 – 4.302)	<0.001*	1.375 (1.032 – 1.760)	0.015*	3.436 (2.748 – 4.295)	<0.001*	2.022 (1.065-2.099)	<0.001*
III + IV vs I + II (516/579)
Histology	1.997 (1.510 – 2.642)	<0.001*	1.655 (1.153 – 2.275)	0.006*	2.012 (1.521 – 2.662)	<0.001*	1.687 (1.177 – 2.419)	0.004*
PD vs MD + WDb (108/952)
Vascular invasion	2.796 (2.261 – 3.457)	<0.001*	1.642 (1.228 – 2.149)	0.001*	2.783 (2.251 – 3.441)	<0.001*	1.623 (1.226 – 2.418)	0.001*
Yes vs No (338/724)
Perineurial invasion	2.437 (1.971 – 3.013)	<0.001*	1.787 (1.358 – 2.351)	<0.001*	2.423 (1.960 – 2.996)	<0.001*	1.765 (1.341 – 2.322)	<0.001*
Yes vs No (391/673)
Pre-op CEAc (ng/ml)	3.047 (2.423 – 3.832)	<0.001*	1.249 (0.902 – 1.729)	0.180	3.053 (2.428 -–3.840)	<0.001*	1.245 (0.899 – 1.723)	0.186
≥5/ vs <5 (475/545)
Post-op CEA c (ng/ml)	5.567 (4.456 – 6.956)	<0.001*	2.492 (1.817 – 3.418)	<0.001*	5.591 (4.474 – 6.986)	<0.001*	2.514 (1.832 – 3.449)	<0.001*
≥5 vs <5 (266/752)
Pre-op albumin (g/dl)	1.847 (1.474 – 2.314)	<0.001*	1.245 (0.933 – 1.662)	0.137	1.828 (1.460 – 2.290)	<0.001*	1.221 (0.915 – 1.630)	0.175
<3.5 vs ≥3.5 (324/572)
Diabetes mellitus	1.012 (0.795 – 1.288)	0.923	0.962 (0.710 – 1.305)	0.804	1.012 (0.795 – 1.288)	0.924	0.949 (0.700 – 1.288)	0.738
Yes vs No (255/840)
Cardiac disease	1.162 (0.947 – 1.427)	0.150	1.016 (0.772 – 1.337)	0.909	1.162 (0.947 – 1.426)	0.151	1.019 (0.774 – 1.342)	0.895
Yes vs No (462/633)
Renal disease	2.583 (1.777 – 3.754)	<0.001*	3.139 (1.854 – 5.317)	<0.001*	2.588 (1.780 – 3.761)	<0.001*	3.101 (1.830 – 5.254)	<0.001*
Yes vs No (52/1043)
Chemotherapy	1.509 (1.188 – 1.916)	<0.001*	1.233 (0.831 – 1.828)	0.298	1.580 (1.188 – 1.915)	0.001*	1.230 (0.830 – 1.824)	0.302
Yes vs No (731/360)

^aAJCC American Joint Commission on Cancer, ^bPD Poorly differentiated, MD Moderately differentiated, WD Well differentiated

^cCEA Carcinoembryonic antigen, ^dHR Hazard ratio, ^eConfidence interval

*Indicated P < 0.05