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. 2015 Aug 27;10(8):e0131854. doi: 10.1371/journal.pone.0131854

Fig 2. Macrophage and VSMC accumulation is reduced in uPAR-/-/LDLR-/-.

Fig 2

(A) Representative Mac-3 immunostaining and (B) %-Mac-3-positive lesion per lesion area. (C) Representative anti-SMC immunostaining and (D) % anti-SMC-positive lesion per lesion area. (E) PCNA/CD68 double staining excludes differences in macrophage proliferation in the lesions. (F) Macrophage apoptosis was not responsible for the differences in macrophage content as evidenced by cleaved caspase 3 staining. Mean±SEM, n = 8. *P<0.05, **P<0.01, ***P<0.001. A/C: Bar = 250 μm, E/F Bar = 100μm αSMA: alpha smooth-muscle-actin, PCNA: Proliferating-Cell-Nuclear-Antigen, cC3: cleaved caspase-3, DAPI: 4′,6-Diamidin-2-phenylindol.