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A model for Toxoplasma ROP16 directly interacting with p53 partially mediates apoptosis and G1 phase arrest in SH-SY5Y. ROP16 overexpressed in SH-SY5Y cells co-localizing and interacting with p53 in the nucleus, influences p53 phosphorylation levels, triggering partially apoptosis and cell cycle arrest in G1 phase.
