TABLE 2.

Apoptosis and Cell-cycle Arrest-associated Genes Expression Changes in SH-SY5Y Cells Overexpressing ROP16

No.	Gene Name	Length	Location	Function	Regulation
1	Casp3	277	Cytoplasm	Promotes apoptosis	Up
2	Casp8	480	Cytoplasm	Promotes apoptosis	Up
3	Casp9	416	Cytoplasm	Promotes apoptosis	Up
4	Bax	192	Cytoplasm	Promotes apoptosis	Up
5	p21	164	Nucleus	Inhibit cellular proliferation	Up
6	Bcl-2	342	Cytoplasm	Inhibit apoptosis	Down
8	SIRT	747	Nucleus	Participates in cell cycle, response to DNA damage, apoptosis and autophagy	Down
13	PUMA	261	Mitochondrion	Promote apoptosis	Up
14	SLTM	1034	Nucleus	Promote apoptosis	Up
15	NOXA	454	Mitochondrion	Promote apoptosis	Up
16	FAS	335	Cell membrane	Apoptosis	Up
17	EP300	2414	Nucleus	Cell cycle	Up
18	E2f1	430	Nucleus	Control cell-cycle progression from G1 to S phase	Down
7	CDKN1B	198	Cytoplasm Nucleus	Induce G1 arrest	UP
19	UBE2L3	154	Cytoplasm Nucleus	Involved in cell cycle progression	Up
20	RB1	928	Nucleus	Induce G1 arrest	UP