Table 5.
Kampo medicines to treat dry mouth and/or Sjögren's syndrome.
| Kampo medicine | Disease, cases | Study design | Effect |
|---|---|---|---|
| Ninjinyoeito (NYT) | Xerostomia induced by oxybutynin (8 cases) |
randomized clinical trial (RCT) Human |
effective |
| Byakkoka ninjinto (BNT) | Increased the expression of aquaporin 5 in rat thirst models | Rat | effective |
| Bakumondoto (BMT) | Dry mouth (excluding Sjögren's syndrome, diabetes mellitus (DM) et al.) 100 cases |
RCT Human |
not effective |
| Primary Sjögren's syndrome 51 cases |
RCT Human |
Effective | |
| Primary Sjögren's syndrome 115 cases (RCT) |
RCT Human |
Effective | |
| Secondary Sjögren's syndrome 424 cases (RCT) |
RCT Human |
Effective | |
| Secondary Sjögren's syndrome 380 cases (RCT) |
RCT Human |
Effective | |
| Secondary Sjögren's syndrome | |||
| Hochuekkito (HET) | Sjögren's syndrome (28 cases) | quasi- RCT Human |
Effective |