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. 2015 Aug 28;5:192. doi: 10.3389/fonc.2015.00192

Figure 1.

Figure 1

The impact of HA depletion from a tumor with an HA-high phenotype. (A) An HA-high tumor, encompassed by a fibrous capsule. As HA accumulates in the tumor it adsorbs water, resulting in expansion of the tumor stroma, which is limited by the fibrous capsule, resulting in increased tumor interstitial pressure, collapse of tumor-associated vasculature, and other sequelae as shown. (B) After treatment with PEGPH20, high-molecular weight HA is degraded to fragments, which diffuse into newly expanded vasculature, resulting in a dose-dependent normalization of tumor interstitial pressure and other changes, which result in tumor growth inhibition and increased access to systemic therapies. Abbreviations: ECM, extracellular matrix; HA, hyaluronan; PEGPH20, pegylated recombinant human hyaluronidase; pO2, partial pressure of oxygen; VEGF, vascular endothelial growth factor. Figure adapted from Ref. (45). Data from Ref. (16, 17, 4044).