Table 2. Potential transcription factors regulating age-related target genes.
| Term | Count | P-value (Benjamini) |
|---|---|---|
| TF binding sites for up-regulated genes | ||
| ELK1 | 614 | 6.25E-017 |
| MAZR | 303 | 3.43E-015 |
| PAX5 | 668 | 5.21E-014 |
| NRF2 | 388 | 2.69E-013 |
| SP1 | 334 | 3.01E-013 |
| ARNT | 571 | 3.09E-013 |
| AHRARNT | 621 | 7.03E-013 |
| YY1 | 785 | 3.97E-011 |
| ROAZ | 539 | 9.38E-011 |
| TF binding sites for down-regulated genes | ||
| MEF2 | 845 | 7.97E-017 |
| SOX5 | 569 | 2.78E-012 |
| HLF | 480 | 4.42E-010 |
| EVI1 | 885 | 5.28E-010 |
| FOXJ2 | 727 | 1.63E-009 |
| FOXO4 | 613 | 2.22E-009 |
| CDP | 668 | 6.69E-009 |
| POU3F2 | 655 | 1.93E-008 |
| FOXO1 | 478 | 1.87E-008 |
The list of the most enriched transcription factors in relation to top scored up- and down-regulated age-related transcripts was derived by motif analysis of promoter sequences, using the default settings of DAVID.