Table 2. The genome-wide haploinsufficiency score evaluates a higher number of genes than three previously published methods, as well as a higher number of less-studied genes.

Score	Total	Without Pubmed paper	Percent without Pubmed paper
GHIS	19 701	4621	23.46%
Huang HIS score	17 069	2064	12.09%
Essentiality score	18 386	1525	8.29%
RVIS	16 572	1774	10.70%

Essentiality score = Khurana et al. (4) gene indispensability score; RVIS = Petrovski et al. (6), Residual Variance Intolerance Score; Huang HIS score = Huang et al. (3) haploinsufficiency probabilities.