Table 3. RWSIP between 100 ns trajectories at different NaCl concentrations and the 500 ns trajectories at 0.1 M.

Molecule	0.0 M	0.1 M	0.5 M	1.0 M
Duplex	0.938	0.998	0.991	0.990
SRD	0.983	0.983	0.982	0.993

For the duplex, only the first half of the 1 µs trajectory was considered, thus discarding the contribution of the base fraying event (see Supplementary Figure S6).