Table 7. K D measured using Biacore 3000.
hEphA2 | ||||
Binder | K D equilibrium (M) | K D kinetic (nM) | K a (1/Ms) | K d (1/s) |
B11 | 1.4x10 -8 | 1.3 x10 -8 | 1.21x106 | 0.0158 |
B6 | 5.6 x10 -8 | 6.9 x10 -8 | 7.16x105 | 0.0496 |
G7 | 2.2 x10 -8 | 2.1 x10 -8 | 1.80x106 | 0.0375 |
hFcRn | ||||
B6 | 3.8 x10 -8 | 1.0 x10 -8 | 1.1x106 | 0.011 |
B11 | 2.6 x10 -8 | 1.2 x10 -8 | 1. 1x106 | 0.013 |
shWTCH2 | 2.5 x10 -8 | 1.1 x10 -8 | 1.5x106 | 0.017 |