Table 3. Albumin kinetic parameters.
Values presented as mean (95% confidence interval), before and 2 days after major pancreatic surgery, n = 10. Plasma volume and transcapillary escape rate were calculated from the slope 0–60 min after isotope injection. Blood volume was calculated from plasma volume and hematocrit assuming an F-ratio of 0.91.
| Day 0 | Day 2 | Difference | p | |
|---|---|---|---|---|
| Plasma albumin concentration [g/L] | 33.5 (30.9, 36.2) | 22.1 (19.8, 24.3) | -11.5 (-13.3, -9.6) | < 0.001 |
| Plasma volume [L] | 3.31 (2.84, 3.78) | 3.32 (2.91, 3.73) | 0.01 (-0.33, 0.35) | 0.97 |
| Blood volume [L] | 5.16 (4.44, 5.88) | 4.45 (3.87, 5.02) | -0.72 (-1.15, -0.28) | 0.005 |
| Intravascular albumin mass [g] | 110 (95, 138) | 73 (61, 85) | -37 (-45, -29) | < 0.001 |
| Fractional synthesis rate [%/d] | 11.7 (8.9, 14.5) | 15.0 (11.7, 18.4) | 3.4 (0.5, 6.2) | 0.027 |
| Absolute synthesis rate [mg/kg/d] | 175 (138, 212) | 150 (107, 192) | -25 (-67, 17) | 0.21 |
| Transcapillary escape rate [%/h] | 4.9 (3.1, 6.8) | 5.5 (3.9, 7.2) | 0.6 (-2.1, 3.4) | 0.63 |
| Albumin mass flow rate [g/h] | 5.1 (3.6, 6.7) | 3.9 (2.8, 5.1) | -1.2 (-3.4, 1.1) | 0.26 |