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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2015 Aug 11;5(1):85–101. doi: 10.1002/wdev.202

Figure 5. Mechanisms for asymmetric cell division of Drosophila neuroblasts.

Figure 5

Several protein complexes localize to the apical neuroblast cortex during mitosis to regulate asymmetric cell division. Insc links the Baz/Par6/aPKC complex to Pins, which in turn forms a complex with Gαi and Mud, thereby coupling cell polarity with mitotic spindle orientation. Mud engages the cytoplasmic dynein motor to exert force on astral microtubules to orient the spindle.