Table 1.
The Protobothrops elegans and P. flavoviridis transcriptomes are overwhelmingly dominated by PLA2s; however, the major PLA2s in each are pharmacologically very different. P. flavoviridis venom appears to be much more anti-coagulant, with coagulation Factor IX/X-binding proteins, and higher percentages of serine proteases, LAO, C-type lectins, 5′-nucleotidase, and phosphodiesterase [14]
| Transcript toxin class | Protobothrops elegans | Protobothrops flavoviridis |
|---|---|---|
| Phospholipase A2 | 77.1 % | 55.5 % |
| Serine protease | 10.4 % | 11.8 % |
| Metalloprotease P-II | 4.8 % | 11.3 % |
| Metalloprotease P-III | 3.2 % | 6.0 % |
| BPP-CNP | 1.4 % | 2.6 % |
| Factor IX/X Activator A | 2.4 % | |
| Factor IX/X Activator B | 1.2 % | |
| LAO | 0.5 % | 3.1 % |
| VEGF | 0.5 % | 1.7 % |
| Phospholipase B | 0.2 % | 0.3 % |
| C-Type Lectin B | 0.2 % | 0.3 % |
| CRISP | 0.1 % | 2.0 % |
| 5′-Nucleotidase | 0.1 % | 0.3 % |
| Nerve Growth Factor | 0.1 % | 0.1 % |
| Phosphodiesterase | 0.1 % | 0.2 % |
| Metalloprotease P-I | 0.1 % | |
| C-Type Lectin A | 0.0 % | 0.6 % |
| Galactose-binding Lectin | 0.0 % | |
| QC | 0.0 % | 0.1 % |
| Hyaluronidase | 0.0 % | |
| DPP-IV | 0.0 % | 0.0 % |
| APA | 0.0 % | 0.0 % |