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. 2015 Jan 2;26(9):2289–2302. doi: 10.1681/ASN.2014040396

Figure 3.

Figure 3.

Doubling of serum creatinine is generally a good surrogate for ESRD. Comparison of the treatment effects on doubling of serum creatinine and ESRD. Treatment effect ratio close to 1 indicates better agreement between the treatment effects; the size of the boxes for the treatment effect ratios (right panel) represent the weight of each study; the treatment effects on doubling of serum creatinine are consistent with the treatment effects on ESRD. ACCOMPLISH, Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension; ACCORD, Action to Control Cardiovascular Disease in Diabetes; ADVANCE, Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation; ALTITUDE, Aliskiren Trial in Type 2 Diabetes Using Cardiorenal Endpoints; CAPRIT, Correction of Anemia and Progression of Renal Insufficiency in Transplant patients; DIABHYCAR, Non-insulin-dependent diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril study; FIELD, Fenofibrate Intervention and Event Lowering in Diabetes; KVT, Kanagawa Valsartan Trial; ONTARGET, ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial; ORIENT, Olmesartan Reducing Incidence of Endstage Renal Disease in Diabetic Nephropathy Trial; SHARP, Study of Heart and Renal Protection; TRANSCEND, Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease; UKPDS, United Kingdom Prospective Diabetes Study; VADT, Veterans Affairs Diabetes Trial.