Table 2.
Morphologic findings of patients with FSGS
| Morphologic Findings | Total | GC-Sensitive Patients | GC-Insensitive Patients | P Value |
|---|---|---|---|---|
| Total cases (n) | 109 | 86 | 23 | |
| FSGS histologic subtype | 0.20 | |||
| Not otherwise specified | 48 (44.0) | 33 (38.4) | 15 (65.2) | |
| Collapsing | 5 (4.6) | 5 (5.8) | 0 | |
| Tip | 37 (33.9) | 32 (37.2) | 5 (21.7) | |
| Cellular | 8 (7.3) | 7 (8.1) | 1 (4.3) | |
| Perihilar | 11 (10.1) | 9 (10.5) | 2 (8.7) | |
| Glomeruli | 26 (21–35) | 26 (21–33) | 27 (15–42) | 0.62 |
| Global glomerulosclerosis (% glomeruli) | 0 (0–6) | 0 (0–5) | 0 (0–7) | 0.74 |
| Segmental glomerulosclerosis (%) | 10.0 (6.6–19.2) | 10.0 (6.1–17.1) | 16.7 (7.1–29.6) | 0.08 |
| Acute tubulointerstitial injury | ||||
| Absent | 12 (11.0) | 9 (10.5) | 3 (13.0) | |
| Mild | 69 (63.3) | 57 (66.3) | 12 (52.2) | |
| Moderate | 19 (17.4) | 13 (15.1) | 6 (26.1) | |
| Severe | 9 (8.3) | 7 (8.1) | 2 (8.7) | |
| Chronic tubulointerstitial injury | ||||
| Absent | 57 (52.3) | 46 (53.5) | 11 (47.8) | |
| Mild | 40 (36.7) | 31 (36.0) | 9 (39.1) | |
| Moderate | 9 (8.3) | 7 (8.1) | 2 (8.7) | |
| Severe | 3 (2.8) | 2 (2.3) | 1 (4.3) | |
| Vascular lesions | 62 (56.9) | 51 (59.3) | 11 (47.8) | 0.32 |
| Electron microscopy findings | ||||
| Podocyte foot process effacement (%) | 85 (73–85) | 80 (65–85) | 85 (80–85) | 0.24 |
Unless otherwise noted, data are presented as number (percentage) or the median (interquartile range). Data described as percentages were analyzed using chi-squared test or Fisher exact test. Other data were compared using Mann–Whitney or Kruskal–Wallis test.