Figure 8.

NPY receptor activation leads to RGC modulation and increases cell survival in the inner retina. (a) NPY receptor location in the different layers of the adult rat retina. (b) The activation of Y₁ receptor leads to decreased Ca²⁺ influx in RGCs, and also increased OFF RGC response, potentially by inhibiting ON-driven surround antagonism in OFF-center RGCs. The activation of Y₁ in RGCs and amacrine cells and Y₅ in Müller cells leads to increased cell survival in the inner retina. GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer.