Table 3.
Analysis of the relationships between APE1 Asp148Glu, APE1 activity and lung cancer risk
A. Association of APE1 Asp148Glu with lung cancer, and with APE1 activity (radioactivity-based)
| Allele | Controls | Cases | Overall | χ 2 for association with lung cancer a | F-test for association with APE1 activity b | |
| All | n | 99 | 99 | 198 (100%) | 0.51 (2 df) | 1.93 (2, 97 df) |
| Mean APE1 (SE) | 793 (21) | 691 (18) | 742 (14) | P = 0.77 | P = 0.15 | |
| T/T | n | 42 | 34 | 76 (38.4%) | ||
| Mean APE1 (SE) | 736 (29) | 673 (33) | 708 (22) | |||
| T/G | n | 46 | 50 | 96 (48.5%) | ||
| Mean APE1 (SE) | 843 (34) | 712 (26) | 774 (22) | |||
| G/G | n | 11 | 15 | 26 (13.1%) | ||
| Mean APE1 (SE) | 804 (53) | 663 (33) | 723 (32) | |||
| Trend | 0.51 (1 df) | 0.39 (1, 98 df) | ||||
| P = 0.48 | P = 0.53 |