Fig. 4.

Association between S. cerevisiae genes whose expression changed along the single or mixed wine fermentations with their documented regulators. The entire dataset of genes found to change their expression throughout the single or the wine fermentations was searched for documented targets of all described S. cerevisiae transcription factors using the tools and information available in the YEASTRACT database. The activity of each transcription factor was predicted based on the number of targets present in each dataset only considering direct regulatory associations in which binding of the transcription factor to the target gene promoter. The dataset of up-regulated genes was only searched for targets of transcriptional activators (a) while the dataset of down-regulated genes was only searched for targets of transcriptional repressors (b). Transcriptional regulators found to work both as transcriptional activators or repressors were included in both analyses. In this figure only a selected set of regulatory associations is shown but the full list is available in Additional file 1