. 2015 Jul 15;182(5):405–416. doi: 10.1093/aje/kwv072

Table 2.

Associations Between Dietary Pattern and Risk of Classic Hodgkin Lymphoma, Overall and by Age Group, Connecticut and Massachusetts, 1997–2000

cHL by Age Group and Quartile	Univariable				Multivariable^a				Multivariable^b
cHL by Age Group and Quartile	No. of Cases	No. of Controls	Odds Ratios	95% CI	No. of Cases	No. of Controls	Odds Ratios	95% CI	No. of Cases	No. of Controls	Odds Ratios	95% CI
	High Vegetable Dietary Pattern
Overall cHL
Quartile 1	118	131	1.00	Referent	118	131	1.00	Referent	118	129	1.00	Referent
Quartile 2	113	137	0.92	0.64, 1.30	113	137	0.94	0.66, 1.34	113	137	0.98	0.67, 1.41
Quartile 3	107	143	0.83	0.58, 1.18	107	143	0.85	0.59, 1.22	107	141	0.87	0.60, 1.27
Quartile 4	97	152	0.71	0.50, 1.01	97	152	0.73	0.50, 1.07	97	151	0.78	0.52, 1.16
P_trend^c			0.05				0.09				0.19
Age <50 years^d
Quartile 1	108	119	1.00	Referent	108	119	1.00	Referent	108	117	1.00	Referent
Quartile 2	97	115	0.93	0.64, 1.35	97	115	0.93	0.64, 1.36	97	115	0.93	0.63, 1.38
Quartile 3	84	107	0.87	0.59, 1.27	84	107	0.86	0.59, 1.27	84	106	0.85	0.57, 1.27
Quartile 4	72	110	0.72	0.49, 1.07	72	110	0.74	0.49, 1.10	72	109	0.76	0.49, 1.16
P_trend^c			0.10				0.13				0.17
Age ≥50 years
Quartile 1	10	12	1.00	Referent	10	12	1.00	Referent	10	12	1.00	Referent
Quartile 2	16	22	0.87	0.30, 2.51	16	22	0.94	0.32, 2.81	16	22	1.12	0.35, 3.51
Quartile 3	23	36	0.77	0.29, 2.06	23	36	0.68	0.24, 1.90	23	35	0.72	0.25, 2.11
Quartile 4	25	42	0.71	0.27, 1.89	25	42	0.51	0.17, 1.49	25	42	0.68	0.22, 2.13
P_trend^c			0.46				0.14				0.34
	Western-Style Dietary Pattern
Overall cHL
Quartile 1	108	141	1.00	Referent	108	141	1.00	Referent	108	139	1.00	Referent
Quartile 2	109	141	1.01	0.71, 1.44	109	141	1.09	0.76, 1.57	109	141	1.09	0.75, 1.59
Quartile 3	104	146	0.93	0.65, 1.33	104	146	1.06	0.72, 1.56	104	144	1.06	0.72, 1.59
Quartile 4	114	135	1.10	0.77, 1.57	114	135	1.38	0.87, 2.20	114	134	1.39	0.86, 2.26
P_trend^c			0.71				0.25				0.26
Age <50 years^d
Quartile 1	91	107	1.00	Referent	91	107	1.00	Referent	91	105	1.00	Referent
Quartile 2	88	105	0.99	0.66, 1.47	88	105	1.03	0.68, 1.55	88	105	1.02	0.67, 1.56
Quartile 3	86	122	0.83	0.56, 1.23	86	122	0.90	0.58, 1.38	86	121	0.89	0.57, 1.39
Quartile 4	96	117	0.97	0.65, 1.42	96	117	1.11	0.66, 1.86	96	116	1.08	0.63, 1.87
P_trend^c			0.67				0.92				0.99
Age ≥50 years
Quartile 1	17	34	1.00	Referent	17	34	1.00	Referent	17	34	1.00	Referent
Quartile 2	21	36	1.17	0.53, 2.58	21	36	1.20	0.52, 2.76	21	36	1.14	0.48, 2.72
Quartile 3	18	24	1.50	0.65, 3.49	18	24	1.79	0.70, 4.54	18	23	1.78	0.67, 4.74
Quartile 4	18	18	2.00	0.83, 4.80	18	18	2.93	0.97, 8.86	18	18	3.34	1.02, 10.91
P_trend^c			0.10				0.05				0.04
	Fruit/Low-Fat Dairy Dietary Pattern
Overall cHL
Quartile 1	118	131	1.00	Referent	118	131	1.00	Referent	118	129	1.00	Referent
Quartile 2	103	147	0.78	0.55, 1.11	103	147	0.75	0.52, 1.07	103	147	0.70	0.48, 1.01
Quartile 3	108	142	0.84	0.59, 1.20	108	142	0.78	0.54, 1.13	108	140	0.80	0.55, 1.18
Quartile 4	106	143	0.82	0.58, 1.17	106	143	0.74	0.49, 1.11	106	142	0.70	0.45, 1.07
P_trend^c			0.38				0.17				0.18
Age <50 years^d
Quartile 1	89	103	1.00	Referent	89	103	1.00	Referent	89	101	1.00	Referent
Quartile 2	90	114	0.91	0.62, 1.36	90	114	0.90	0.60, 1.34	90	114	0.86	0.57, 1.30
Quartile 3	89	110	0.94	0.63, 1.39	89	110	0.89	0.59, 1.36	89	109	0.94	0.61, 1.46
Quartile 4	93	124	0.87	0.59, 1.28	93	124	0.85	0.54, 1.33	93	123	0.83	0.51, 1.34
P_trend^c			0.53				0.49				0.55
Age ≥50 years
Quartile 1	29	28	1.00	Referent	29	28	1.00	Referent	29	28	1.00	Referent
Quartile 2	13	33	0.38	0.17, 0.87	13	33	0.33	0.14, 0.78	13	33	0.24	0.10, 0.62
Quartile 3	19	32	0.57	0.27, 1.24	19	32	0.53	0.23, 1.18	19	31	0.43	0.18, 1.04
Quartile 4	13	19	0.66	0.28, 1.59	13	19	0.50	0.19, 1.33	13	19	0.42	0.15, 1.19
P_trend^c			0.33				0.17				0.13
	Desserts/Sweets Dietary Pattern
Overall cHL
Quartile 1	92	157	1.00	Referent	92	157	1.00	Referent	92	155	1.00	Referent
Quartile 2	106	144	1.26	0.88, 1.80	106	144	1.21	0.84, 1.74	106	144	1.16	0.80, 1.69
Quartile 3	120	130	1.58	1.10, 2.25	120	130	1.56	1.09, 2.24	120	128	1.49	1.03, 2.17
Quartile 4	117	132	1.51	1.06, 2.16	117	132	1.59	1.10, 2.30	117	131	1.50	1.02, 2.21
P_trend^c			0.01				0.005				0.02
Age <50 years^d
Quartile 1	80	135	1.00	Referent	80	135	1.00	Referent	80	133	1.00	Referent
Quartile 2	89	125	1.20	0.82, 1.77	89	125	1.16	0.79, 1.72	89	125	1.10	0.73, 1.65
Quartile 3	101	97	1.76	1.19, 2.60	101	97	1.73	1.17, 2.57	101	96	1.63	1.08, 2.46
Quartile 4	91	94	1.63	1.10, 2.44	91	94	1.69	1.12, 2.54	91	93	1.60	1.05, 2.45
P_trend^c			0.004				0.002				0.008
Age ≥50 years
Quartile 1	12	22	1.00	Referent	12	22	1.00	Referent	12	22	1.00	Referent
Quartile 2	17	19	1.64	0.63, 4.29	17	19	1.33	0.49, 3.59	17	19	1.43	0.48, 4.23
Quartile 3	19	33	1.06	0.43, 2.60	19	33	0.90	0.35, 2.26	19	32	0.78	0.28, 2.21
Quartile 4	26	38	1.25	0.53, 2.97	26	38	1.07	0.43, 2.70	26	38	0.94	0.34, 2.61
P_trend^c			0.90				0.87				0.60

Abbreviations: cHL, classic Hodgkin lymphoma; CI, confidence interval.

^a Logistic regression models adjusted for sex, age (overall only), state of residence, total daily caloric intake, and body mass index.

^b Logistic regression models additionally adjusted for race, alcohol intake, smoking, education, attended nursery school >1 year, number of siblings, regular aspirin use, and regular acetaminophen use.

^c Test for trend across quartiles from logistic regression model, modeling the median of each quartile as a semicontinuous variable.

^d Age defined as age at diagnosis (years) for cases and age at study entry for controls.