Table 5. Genotype and allele frequencies in control and AMD patients for IL-6 SNPs.
| Genotype | t test |
Control (N=100) |
AMD (N=90) |
Alleles | Allele frequency reported in Pakistan (%) [25] |
Control |
AMD |
p value | ||
|---|---|---|---|---|---|---|---|---|---|---|
| p value | F value | p value | F value | HWE allele frequency | HWE allele frequency | |||||
| rs1800795 |
|
|||||||||
| GG |
0.0001*** |
0.105 |
2.707 |
0.0001*** |
8.801 |
G |
87 |
0.865 (86.5%) |
0.633 (63.3%) |
0.0001*** |
| GC |
0.916 |
C |
13 |
0.135 (13.5%) |
0.367 (36.7%) |
|||||
| CC |
NA |
|
||||||||
|
rs1800796 |
|
|||||||||
| GG |
0.010* |
0.514 |
0.671 |
0.293 |
1.254 |
G |
67 |
0.59 (59%) |
0.583 (58.3%) |
0.896 |
| GC |
0.0001*** |
C |
33 |
0.41 (41%) |
0.417 (41.7%) |
|||||
| CC |
0.044* |
|
||||||||
|
rs1800797 |
|
|||||||||
| GG |
0.0001*** |
3.154 | 0.081 | 0.254 | 0.616 | G |
86 |
0.82 (82%) |
0.96 (96%) |
0.0001*** |
| GA |
0.733 |
A |
14 |
0.18 (18%) |
0.04 (4%) |
|||||
| AA | NA | |||||||||
HWE: Hardy Weinberg Equilibrium; NA: none of the subject had this genotype therefore t test was not available; *p < 0.05; ***p < 0.0001