Table 6. Genotype and allele frequencies in control and AMD patients for IL-8 SNPs.
| Genotype | t test |
Control (N=100) |
AMD (N=90) |
Alleles | Allele frequency reported in Pakistan (%) [25] |
Control |
AMD |
p value | ||
|---|---|---|---|---|---|---|---|---|---|---|
| p value | F value | p value | F value | HWE allele frequency | HWE allele frequency | |||||
|
rs4073 |
|
|||||||||
| TT |
0.0001*** |
0.368 |
1.015 |
0.340 |
1.099 |
T |
64 |
0.625 (62.5%) |
0.589 (58.9%) |
0.2366 |
| AT |
0.007** |
A |
36 |
0.375 (37.5%) |
0.411 (41.1%) |
|||||
| AA |
0.146 |
|
||||||||
|
rs2227306 |
|
|||||||||
| CC |
0.0001*** |
0.125 |
2.148 |
0.951 |
0.050 |
C |
74 |
0.73 (73%) |
0.84 (84%) |
0.0001*** |
| CT |
0.0001*** |
T |
26 |
0.27 (27%) |
0.16 (16%) |
|||||
| TT |
0.137 |
|
||||||||
|
rs2227543 |
|
|||||||||
| CC |
0.0001*** |
0.710 | 0.495 | 0.002** | 6.80 | C |
68 |
0.66 (66%) |
0.555 (55.5%) |
0.0372 |
| CT |
0.0001*** |
T |
32 |
0.34 (34%) |
0.445 (45.5%) |
|||||
| TT | 0.833 | |||||||||
HWE: Hardy Weinberg Equilibrium; **p < 0.01; ***p < 0.0001