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. Author manuscript; available in PMC: 2015 Aug 28.
Published in final edited form as: Psychiatry Res. 2012 Nov 13;211(3):214–220. doi: 10.1016/j.pscychresns.2012.07.003

Table 2.

Summary of top SNPs associated with volumetric measures

SNP CHR A1 Genes MAF N BETA STAT P Adjusted Empirical P value Phenotype
rs6558484 8 C DLGAP2 0.45 17 −1.373 −4.53 0.000565 0.3071 OFC (White Matter)
rs7014992 8 G DLGAP2 0.45 17 −1.373 −4.53 0.000565 0.3071 OFC (White Matter)
rs1116345 18 T DLGAP1 0.3 19 1.726 3.951 0.001282 0.3884 ACC Volume
rs342483 18 C DLGAP1 0.3 19 1.726 3.951 0.001282 0.3884 ACC Volume
rs6994849 8 A DLGAP2 0.475 17 −3.605 −4.061 0.001348 0.4504 OFC Volume
rs10814988 9 A SLC1A1 0.2 19 2 3.86 0.001541 0.4032 ACC (Grey Matter)
rs1558024 8 G DLGAP2 0.475 17 3.343 3.985 0.001555 0.4856 OFC Volume
rs3738081 8 C GRIK3 0.475 19 0.9366 3.789 0.001781 0.45 ACC (White Matter)
rs6558484 8 C DLGAP2 0.45 17 −3.728 −3.911 0.001789 0.5223 OFC Volume
rs7014992 8 G DLGAP2 0.45 17 −3.728 −3.911 0.001789 0.5223 OFC Volume
rs8097308 18 C DLGAP1 0.475 17 0.9312 3.899 0.001828 0.5664 OFC(White Matter)
rs2956913 8 G DLGAP2 0.45 17 3.087 3.754 0.002411 0.6038 OFC Volume
rs11612284 12 A GRIN2B 0.2 20 2.138 3.565 0.002584 0.6546 Thalamus Volume
rs10094463 8 A DLGAP2 0.475 17 4.265 3.685 0.002749 0.6425 OFC Volume
rs301430 9 C SLC1A1 0.45 20 −1.469 −3.456 0.003251 0.6401 Thalamus Volume
rs11842338 13 A SLITRK5 0.175 20 −2.229 −3.436 0.003394 0.6546 Thalamus Volume
rs12215960 6 G GRIK2 0.15 19 0.7756 3.451 0.003567 0.6794 ACC(White Matter)
rs10459061 12 A GRIN2B 0.1 19 −2.444 −3.39 0.004038 0.7135 ACC(Grey Matter)
rs17833967 12 C GRIN2B 0.1 19 −2.444 −3.39 0.004038 0.7135 ACC(Grey Matter)
rs7541937 1 T DLGAP3 0.45 17 0.8712 3.463 0.004203 0.7758 OFC(White Matter)
rs2301963 8 C DLGAP2 0.475 17 −1.355 −3.443 0.004366 0.7844 OFC(White Matter)
rs10485270 6 A GRIK2 0.175 19 0.7689 3.328 0.00459 0.76 ACC(White Matter)
rs9390764 6 A GRIK2 0.175 19 0.7689 3.328 0.00459 0.76 ACC(White Matter)
rs1116345 18 T DLGAP1 0.3 19 1.255 3.327 0.004596 0.7934 ACC(Grey Matter)
rs342483 18 C DLGAP1 0.3 19 1.255 3.327 0.004596 0.7543 ACC(Grey Matter)
rs1558024 8 G DLGAP2 0.475 17 1.071 3.406 0.004692 0.7844 OFC(White Matter)
rs2956929 8 A DLGAP2 0.5 17 2.833 3.401 0.004733 0.7898 OFC Volume
rs2300266 12 G GRIN2B 0.175 20 1.797 3.275 0.004766 0.7638 Thalamus Volume

A1: Minor allele

MAF: minor allele frequency

N: number of subjects with non-missing data for the brain region volume.

Beta: Regression coefficient (non-standardized)

STAT: Coefficient t-statistic

Adjusted Empirical P value: based on max (T) permutation (n = 50,000)

ACC: Anterior Cingulate Cortex

OFC: Orbital Frontal Cortex