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Kinetic rate constants of nano-conjugates and free Herceptin with Her2 receptors in intact SKBR3 and JIMT1 cells
| ka1 (106 M−1s−1) | kd1 (10−3 s−1) | KD1 (nM) | ka2 (10−6 RU·s−1) | kd2 (10−3 s−1) | |
|---|---|---|---|---|---|
| Herceptin@AuNP-JIMT1 | 0.62±0.07 | 8.45±6.15 | 13.32±8.71 | 0.12±0.09 | 1.17±0.64 |
| Herceptin@AuNP-SKBR3 | 2.81±1.64 | 16.64±4.73 | 8.06±4.82 | 0.85±0.36 | 0.26±0.11 |
| Herceptin-SKBR3 | 0.13±0.04 | 0.34±0.26 | 2.70±2.01 |
