Table 4. Major signature amino acid substitutions.
| Vic-1 | Yam-3 | ||||||
|---|---|---|---|---|---|---|---|
| Vic-1A | |||||||
| Protein | V1A-1 | V1A-2 | Vic-1B | Yam-2 | Stockholm/12-like | Wisconsin/01-like | Phuket/3073-like |
| HA | N75K | R48K | S150I | ||||
| N165K | P108A | N165Y | |||||
| S172P | T181A | D196N | |||||
| I146V | L58P | D196N | G229D | ||||
| H122Y | V29A | N116K | |||||
| A202E | L172Q | K298E | |||||
| M251V | E312K | ||||||
| L172Q | |||||||
| NA | I204V | I148V | Q42R | ||||
| A358E | T106I | A68T | |||||
| D329N | S295R | T125K | |||||
| N340D | K186R | ||||||
| A389T | D463N | ||||||
| S295R | A465T | ||||||
| E358K | D340N | N340D | |||||
| L73P | L73P | ||||||
| K343E | K343E | ||||||
| I45V | |||||||
| E320K | |||||||
Amino acid substitutions are numbered according to vaccine strains (B/Brisbane/60/2008 for Vic-1, B/Massachusetts/02/2012 for Yam-2, B/Wisconsin/01/2010 for Yam-3). Bold and italic text indicates substitutions shared by two subclades or more.