Table 2. Associations of clinicopathological variables with PD-1 (in TILs) or PD-L1 (in NSCLC cells).
| Variables | PD-1 (+) in TILs p-value* n (%) | PD-L1 (+) in NSCLC p-value* n (%) | |
|---|---|---|---|
| Age | p-value | 0.887 | 0.580 |
| <70 years | 47 (22%) | 49 (23%) | |
| ≥70 years | 25 (23%) | 28 (26%) | |
| Sex | p-value | 0.260 | 0.637 |
| Male sex | 60 (24%) | 62 (25%) | |
| Female sex | 12 (17%) | 15 (21%) | |
| Smoking status | p-value | 0.384 | 0.315 |
| Non-smoker | 10 (16%) | 18 (30%) | |
| Smoker or ex-smoker | 57 (23%) | 57 (23%) | |
| Performance status | p-value | 0.120 | 0.867 |
| ECOG 0 | 18 (31%) | 15 (25%) | |
| ECOG ≥1 | 52 (21%) | 61 (24%) | |
| Adjuvant therapy | p-value | 0.849 | 0.712 |
| No adjuvant therapy | 61 (22%) | 65 (24%) | |
| Adjuvant therapy | 11 (24%) | 12 (26%) | |
| Tumor stage | p-value | 0.498 | 0.508 |
| Stage I | 39 (21%) | 42 (23%) | |
| Stage ≥1I | 33 (25%) | 35 (26%) | |
| Tumor size | p-value | 0.664 | 0.481 |
| pT1 | 24 (24%) | 21 (21%) | |
| pT2-4 | 48 (22%) | 56 (25%) | |
| Lymph nodes status | p-value | 0.489 | 0.892 |
| pN0 | 43 (21%) | 48 (24%) | |
| pN1-3 | 29 (25%) | 29 (25%) | |
| Tumor histology | p-value | 0.505 | 0.089 |
| Squamous cell carcinoma | 36 (21%) | 48 (28%) | |
| Non squamous cell carcinoma | 36 (24%) | 29 (20%) | |
| Tumor grading | p-value | 1.000 | 0.786 |
| < G2 | 25 (22%) | 29 (25%) | |
| ≥ G2 | 44 (22%) | 47 (24%) | |
| Apoptosis | p-value | 0.523 | 0.162 |
| Negative Bcl-2 expression | 50 (22%) | 52 (23%) | |
| Positive Bcl-2 expression | 19 (26%) | 23 (31%) | |
| p-value | 0.464 | 0.013 | |
| Negative Bcl-xl expression | 41 (21%) | 36 (18%) | |
| Positive Bcl-xl expression | 25 (25%) | 32 (32%) | |
| EGFR mutation status | p-value | 0.288 | 1.000 |
| No EGFR mutation | 7 (32%) | 8 (36%) | |
| EGFR mutation | 0 | 2 (33%) | |
| Proliferation (ki-67) | p-value | 0.756 | 0.287 |
| Negative ki-67 expression | 16 (21%) | 22 (29%) | |
| Positive ki-67 expression | 56 (23%) | 55 (23%) | |
| PD-1 expression in tumor Infiltrating lymphocytes (TILs) | p-value | 1.000 | |
| negative lymphocytic expression | 60 (24%) | ||
| negative lymphocytic expression | 17 (24%) | ||
| PD-L1 expression in NSCLC | p-value | 1.000 | |
| negative tumor expression | 55 (23%) | ||
| positive tumor expression | 17 (22%) | ||
*p values according to Fisher’s exact test.