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. 2014 Sep 24;18:12. doi: 10.1186/2055-7124-18-12

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© You et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histological view of rabbit calvarial defect. (A) Collagen membrane (Bio-Gide^®) group at 4 weeks, and (B) 8 weeks. (C) Monolayer PLGA membrane group at 4 weeks, and (D) 8 weeks. (E) 3-layer PLGA (5% HA gel) membrane group at 4 weeks, and (F) 8 weeks. (G) 3-layer PLGA (10% HA gel) membrane group at 4 weeks, and (H) 8 weeks. H-E stain. (Left - ×40, Right - ×100) (arrowhead: defect margin, BV: blood vessel, NB: new bone, CM: collagen membrane, AT: adipose tissue, IT: inflamed tissue, FT: fibrous tissue, HS: hydrogel scaffold).