Table 2.
Results of logistic regression analysis investigating the effect of age, gender and HbS genotype on malaria status as determined by microscopya using combined data.
| Factor | Adjusted OR (95 % CI) | p-value | Malaria status by microscopy | |||
|---|---|---|---|---|---|---|
| Individuals positive (total = 1,966) | Individuals negative (total = 7,261) | |||||
| N | (%) | N | (%) | |||
| Age (years) | ||||||
| <1 | 1 | 37 | (10.9) | 303 | (89.1) | |
| 1–2 | 1.33 (0.87–2.05) | 0.191 | 47 | (17.2) | 225 | (82.7) |
| 2–5 | 2.65 (1.88–3.72) | <0.001 | 311 | (26.7) | 854 | (73.3) |
| 5–15 | 3.49 (2.53–4.86) | <0.001 | 1,141 | (25.6) | 3,314 | (74.4) |
| 15–30 | 1.21 (0.87–1.70) | 0.263 | 281 | (17.1) | 1,365 | (82.9) |
| >30 | 0.63 (0.44–0.90) | 0.010 | 147 | (11.1) | 1,177 | (88.9) |
| Gender | ||||||
| Female | 1 | 1,044 | (20.1) | 4,142 | (79.9) | |
| Male | 1.09 (0.98–1.21) | 0.109 | 922 | (22.8) | 3,119 | (77.2) |
| HbS | ||||||
| 11 | 1 | 1,824 | (21.4) | 6,718 | (78.6) | |
| 12 | 0.75 (0.61–0.92) | 0.005 | 136 | (21.1) | 508 | (78.9) |
| 22 | ND | ND | 0 | (0) | 8 | (100) |
Data from Senegal, Mali (Pongonon), Sudan and Sri Lanka are not included as participants are either entirely microscopically malaria-positive or malaria-negative.
Reference category is “negative” (n = 7261).
Results significant at 0.05 level are highlighted in italics.
ND: Results not shown as unable to obtain estimates for HbSS without any infected individuals.
NB: CI confidence interval, OR odds ratio.
aAlso adjusted for altitude, village (>20), ethnicity (>20), sample month (>20) and study; results not shown.