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. 2015 Aug 28;15:212. doi: 10.1186/s12870-015-0562-x

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© Upadhyay et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Number of genes involved in specialized metabolite synthesis in Tulsi genome. a. There are four classes of metabolites present in Ocimum genome viz., sesquiterpenes (52 %), flavonoids (19 %), terpenes (18 %) and phenylpropanoids (11 %). Number in the bracket is percentage of sepecialized metabolites present in the genome. 458 genes were identified as coding for enzymes involved in synthesis of specialized metabolites. b. Specialized metabolic pathways of disease relevance proposed in Ocimum tenuiflorum. Major classes of diseases investigated are indicated in different colors: anticancer , anticancer-antioxidant , antifungal , antiseptic , anti-infective , antioxidant , and anti-inflammatory . The enzymes have been labelled with 5–7 letters for convenience. The numbers after the’_’ in the enzyme label represent the number of putative hits found for the given enzyme in the genomic assembly of O. tenuiflorum. The metabolites involved in the disease relevance and the enzymes involved in the synthesis of these metabolites are as follows: APIGENIN (Flavone-synthaseI-FSYN1, Naringenin-NADPH-oxygen-oxidoreductase-NNOOX), LUTEOLIN (Flavone-synthaseI-FSYN1, Naringenin-NADPH-oxygen-oxidoreductase-NNOOX, Flavone-3-monooxygenase-F3MON), TAXOL (Taxadiene-synthase-TSYN, Taxadiene-5-alpha-hydroxylase-T5AHYD, Taxadien-5-alpha-ol-O-acetyltransferase-T5AOOA, Taxane-10-beta-hydroxylase-T10BHYD, Taxoid-14-beta-hydroxylase-T14BHYD, 2-alpha-hydroxytaxane-2-O-benzoyltransferase-2AH2OB, 10-deacetylbaccatin-III-10-O-acetyltransferase-10D10OA, 3-N-debenzoyl-2-deoxytaxol-N-benzoyltransferase-3ND2DNB, URSOLIC ACID (ursolic-aldehyde-28-monooxygenase-UA28M, Alpha-amyrin-synthase-AASYN), OLEANOLIC ACID (Beta-amyrin-synthase-BASYN, oleanolic-aldehyde-28-monooxygenase-OA28M), SITOSTEROL (24C-methyltransferase-24CMET), ROSMARINIC ACID I (4-coumaroyl-4-hydroxyphenyllactate-3-hydroxylase-4C4H3H, Tyrosine-transaminase-TTRAN), ROMARINIC ACID II (Hydroxyphenylpyruvate-reductase-HPPRE, Tyrosine-3-monooxygenase-TTRAN), METHYL CAHVICOL (Eugenol-o-methyltransferase-EOMET), EUGENOL (Alcohol-o-acetyltransferase-AOACE, Eugenol-synthase-ESYN, Isoeugenol-synthase-ISYN), LINALOOL (Farnesyl-pyrophosphate-synthase-FPSYN, R-linool-synthase-RLSYN, S-linool-synthase-SLSYN), CARYOPHYLENE (Alpha-humulene-synthase-AHSYN, Beta-caryophyllene-synthase-BCSYN), SELINENE (Alpha-selinene-synthase-ASSYN, Beta-selinene-synthase-BSSYN), CITRAL (Geraniol-synthase-GSYN, Geraniol-dehdrogenase-GDHYD)

Inline graphic — Number of genes involved in specialized metabolite synthesis in Tulsi genome. a. There are four classes of metabolites present in Ocimum genome viz., sesquiterpenes (52 %), flavonoids (19 %), terpenes (18 %) and phenylpropanoids (11 %). Number in the bracket is percentage of sepecialized metabolites present in the genome. 458 genes were identified as coding for enzymes involved in synthesis of specialized metabolites. b. Specialized metabolic pathways of disease relevance proposed in Ocimum tenuiflorum. Major classes of diseases investigated are indicated in different colors: anticancer , anticancer-antioxidant , antifungal , antiseptic , anti-infective , antioxidant , and anti-inflammatory . The enzymes have been labelled with 5–7 letters for convenience. The numbers after the’_’ in the enzyme label represent the number of putative hits found for the given enzyme in the genomic assembly of O. tenuiflorum. The metabolites involved in the disease relevance and the enzymes involved in the synthesis of these metabolites are as follows: APIGENIN (Flavone-synthaseI-FSYN1, Naringenin-NADPH-oxygen-oxidoreductase-NNOOX), LUTEOLIN (Flavone-synthaseI-FSYN1, Naringenin-NADPH-oxygen-oxidoreductase-NNOOX, Flavone-3-monooxygenase-F3MON), TAXOL (Taxadiene-synthase-TSYN, Taxadiene-5-alpha-hydroxylase-T5AHYD, Taxadien-5-alpha-ol-O-acetyltransferase-T5AOOA, Taxane-10-beta-hydroxylase-T10BHYD, Taxoid-14-beta-hydroxylase-T14BHYD, 2-alpha-hydroxytaxane-2-O-benzoyltransferase-2AH2OB, 10-deacetylbaccatin-III-10-O-acetyltransferase-10D10OA, 3-N-debenzoyl-2-deoxytaxol-N-benzoyltransferase-3ND2DNB, URSOLIC ACID (ursolic-aldehyde-28-monooxygenase-UA28M, Alpha-amyrin-synthase-AASYN), OLEANOLIC ACID (Beta-amyrin-synthase-BASYN, oleanolic-aldehyde-28-monooxygenase-OA28M), SITOSTEROL (24C-methyltransferase-24CMET), ROSMARINIC ACID I (4-coumaroyl-4-hydroxyphenyllactate-3-hydroxylase-4C4H3H, Tyrosine-transaminase-TTRAN), ROMARINIC ACID II (Hydroxyphenylpyruvate-reductase-HPPRE, Tyrosine-3-monooxygenase-TTRAN), METHYL CAHVICOL (Eugenol-o-methyltransferase-EOMET), EUGENOL (Alcohol-o-acetyltransferase-AOACE, Eugenol-synthase-ESYN, Isoeugenol-synthase-ISYN), LINALOOL (Farnesyl-pyrophosphate-synthase-FPSYN, R-linool-synthase-RLSYN, S-linool-synthase-SLSYN), CARYOPHYLENE (Alpha-humulene-synthase-AHSYN, Beta-caryophyllene-synthase-BCSYN), SELINENE (Alpha-selinene-synthase-ASSYN, Beta-selinene-synthase-BSSYN), CITRAL (Geraniol-synthase-GSYN, Geraniol-dehdrogenase-GDHYD)