Table 1.
Brain and cardiovascular responses to repetitive umbilical cord occlusions.
| Baseline | Mild UCO | Mod UCO | Sev UCO | Pattern | |||||
|---|---|---|---|---|---|---|---|---|---|
| dur UCO | btw UCO | dur UCO | btw UCO | dur UCO | btw UCO | dur UCO | btw UCO | ||
| ECoG amplitude, μV | 127 ± 14 | 130 ± 14 | 131 ± 14 | 152 ± 29 | 152 ± 29 | 140 ± 24 | 156 ± 26 | 102 ± 172 | 209 ± 26 |
| ECoG SEF (95%), Hz | 6.7 ± 0.6 | 8.2 ± 0.51 | 8.1 ± 0.51 | 7.6 ± 0.3 | 7.5 ± 0.4 | 6.0 ± 0.4 | 5.9 ± 0.3 | 11.0 ± 0.42 | 8.6 ± 0.5 |
| EEG amplitude, μV | 37 ± 44 | 61 ± 134 | 66 ± 144 | 48 ± 114 | 56 ± 124 | 73 ± 114 | 102 ± 131 | 81 ± 82 | 138 ± 174 |
| EEG SEF (95%), Hz | 4.4 ± 0.34 | 5.2 ± 0.94 | 5.0 ± 0.94 | 5.4 ± 0.84 | 4.3 ± 0.44 | 4.7 ± 0.44 | 4.4 ± 0.24 | 9.0 ± 0.72 | 8.1 ± 0.7 |
| FHR, bpm | 159 ± 5 | 165 ± 5 | 162 ± 3 | 131 ± 61 | 153 ± 2 | 115 ± 101 | 162 ± 3 | 101 ± 62 | 171 ± 8 |
| ABP, mmHg | 44 ± 2 | 48 ± 21 | 49 ± 21 | 54 ± 21 | 53 ± 21 | 60 ± 21 | 60 ± 11 | 57 ± 2 | 60 ± 2 |
| ABPmax, mmHg | 64 ± 32 | 74 ± 32 | 88 ± 22 | 65 ± 3 | |||||
| ABPmin, mmHg | 32 ± 22 | 37 ± 2 | 36 ± 2 | 33 ± 3 | |||||
| FHRnadir, bpm | 123 ± 82,3 | 95 ± 52 | 63 ± 52 | 80 ± 6 | |||||
| ΔFHR, bpm | 39 ± 82,3 | 59 ± 42,3 | 99 ± 72 | 90 ± 11 | |||||
| ΔABPUCO, mmHg | 33 ± 3 | 37 ± 3 | 52 ± 22,3 | 32 ± 2 | |||||
| ΔABP, mmHg | 16 ± 22,3 | 20 ± 22,3 | 28 ± 22,3 | 4 ± 3 | |||||
UCO, umbilical cord occlusion; during, during UCO; between, between UCO; ECoG, electrocorticogram; EEG, electroencephalogram; SEF, 95% spectral edge frequency of ECoG or EEG; Cardiovascular measures “between UCO”: FHR, fetal heart rate; ABP, mean arterial blood pressure; Cardiovascular measures “during UCO”: ABPmax, maximal ABP during a UCO; ABPmin, minimal ABP during a UCO; FHRnadir, minimal FHR during a UCO; ΔFHR, FHR deceleration depth during UCO; ΔABPUCO, difference between ABPmax and ABPmin during UCO; ΔABP, difference between ABPmax and mean ABP between UCO.
“Pattern” denotes the time segment of the UCO series when synchronized ECOG/EEG-FHR activities were observed (i.e., adaptive brain shut-down).
Mean ± SEM. 1, versus baseline; 2, pairwise (i.e., during vs. between UCO or vs. another “during UCO” measurement for ABPmax, FHRnadir, ΔFHR, ΔABP, and ΔABPUCO); 3, versus the respective variable during Pattern; 4, EEG versus ECoG at the same time point.