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. 2015 Jul 14;3(7):e12436. doi: 10.14814/phy2.12436

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of 2 months of chronic treatment with luseogliflozin, lisinopril, combination therapy and insulin on the degree of renal medullary fibrosis (A) and the formation of protein casts (B) in Dahl-STZ rats. Numbers in parenthesis indicate the number of rats and areas in which a complete data set was collected per group. ^#Indicates a significant difference from the corresponding values in the baseline control group of Dahl salt-sensitive rats. *Indicates a significant difference from the corresponding value in vehicle-treated rats. ^†Indicates a significant difference from the corresponding value in luseogliflozin-treated rats. ^‡Indicates a significant difference from the corresponding value in lisinopril-treated rats.