Table 3.

Cerebrovascular and cardiorespiratory variables during graded systemic hypoxia.

	Placebo		Indo
	Men	Women	Men	Women
MABP (mmHg)2,3
Baseline	90 ± 1	89 ± 1	95 ± 2	94 ± 1
90%	94 ± 1	93 ± 2	97 ± 2	94 ± 1
80%	94 ± 1	91 ± 2	98 ± 2	95 ± 1
HR (beats min−1)1,2,4
Baseline	65 ± 5	70 ± 2	67 ± 6	62 ± 2
90%	75 ± 4	82 ± 2	70 ± 4	71 ± 2
80%	79 ± 3	89 ± 2	73 ± 2	76 ± 3
PETco2 (mmHg)1
Baseline	40 ± 1	38 ± 0	38 ± 1	37 ± 1
90%	40 ± 1	38 ± 0	38 ± 1	38 ± 0
80%	39 ± 1	38 ± 0	38 ± 1	38 ± 1
SpO2 (%)2,4
Baseline	99 ± 0	99 ± 0	99 ± 0	99 ± 0
90%	90 ± 0	90 ± 0	90 ± 0	90 ± 0
80%	80 ± 0	81 ± 0	80 ± 0	81 ± 0
MCAv (cm sec−1)1,2,3,4
Baseline	73 ± 3	78 ± 3	49 ± 2	54 ± 2
90%	78 ± 3	86 ± 4	53 ± 3	59 ± 3
80%	86 ± 4	93 ± 4	62 ± 3	65 ± 3
ΔMCAv2,4
90%	5 ± 1	8 ± 1	4 ± 1	6 ± 1
80%	13 ± 2	14 ± 1	12 ± 1	11 ± 1
% ΔMCAv 2,4
90%	7 ± 2	10 ± 2	9 ± 2	11 ± 2
80%	17 ± 2	18 ± 2	25 ± 3	20 ± 2
CVCi (cm sec−1 mmHg−1)1,2,3,4
Baseline	82 ± 4	88 ± 4	52 ± 3	57 ± 2
90%	84 ± 4	93 ± 4	55 ± 3	63 ± 3
80%	92 ± 4	102 ± 4	63 ± 3	68 ± 4
Δ CVCi2,4
90%	2 ± 2	5 ± 1	3 ± 1	6 ± 1
80%	10 ± 2	13 ± 1	11 ± 2	11 ± 2
% Δ CVCi2,4
90%	2 ± 2	6 ± 2	7 ± 2	11 ± 2
80%	13 ± 2	16 ± 2	22 ± 3	18 ± 2

Values are means ± SE. Indo, indomethacin; MABP, mean arterial blood pressure; HR, heart rate; PET_CO2, end-tidal carbon dioxide; S_PO₂, pulse oximetry oxygen saturation; MCAv, middle cerebral artery velocity; ΔMCAV, change in MCAv from baseline; %ΔMCAV, percent change in MCAv from baseline; CVCi, cerebrovascular conductance index; ΔCVCi, change in CVCi from baseline; %ΔCVCi, percent change in CVCi from baseline.

¹Placebo, main effect of group.

²Placebo, main effect of hypoxia.

³Indo, main effect of group.

⁴Indo, main effect of hypoxia; P < 0.05.