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. 2015 Jul 21;3(7):e12459. doi: 10.14814/phy2.12459

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of endothelin-1 receptor blockade with tezosentan (TEZO) and nitric oxide synthase inhibition (L-NAME) on acethylcholine (ACh)-induced vasorelaxation of thoracic aortic rings of low-capacity running (LCR) and high-capacity running (HCR) rats. The left panel (A and B) present data from ACh dose-response curves in HCR, and right panel (C and D) present data from ACh dose-response curves in LCR. Closed circles represent % relaxation in response to ACh alone, open triangles represent % relaxation to ACh in the presence of 3 μM tezosentan, a nonspecific inhibitor of ET-1 receptors (top panel, A and C) N = 9–16/group, and open squares represent % relaxation to insulin in the presence of 300 μM L-NAME, a nitric oxide synthase inhibitor, (bottom panel, B and D) N = 6–8/group. Values are expressed as means ± SEM *Denotes line difference (P < 0.05).