Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 21;3(7):e12459. doi: 10.14814/phy2.12459

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Effects of endothelin-1 receptor blockade with tezosentan (TEZO) and nitric oxide synthase inhibition (L-NAME) on insulin-mediated vasorelaxtion of thoracic aortic rings of low-capacity running (LCR) and high-capacity running (HCR) rats. The left panels (A and B) present data from insulin dose-response curves in HCR, and right panel (C and D) present data from insulin dose-response curves in LCR. Closed circles represent % relaxation in response to insulin alone, open triangles represent % relaxation to insulin in the presence of 3 μM TEZO a nonspecific inhibitor of ET-1 receptors (top panel, A and C) N = 9–16/group, and open squares represent % relaxation to insulin in the presence of 300 μM L-NAME, a nitric oxide synthase inhibitor, (bottom panel, B and D) N = 6–8/group. Insulin μIU/mL, micro-international units per milliliter. Values are expressed as means ± SEM. *Denotes line difference (P < 0.05).