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. 2015 Aug 28;10(8):e0136599. doi: 10.1371/journal.pone.0136599

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© 2015 Bufalino et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — (A) Activin A treatment induced significantly the adhesion of HaCat cells on surfaces coated with type I collagen, fibronectin or laminin. (B) Follistatin decreased significantly the adhesion of SCC-9 ZsGreen LN-1 cells o surfaces coated with type I collagen and fibronectin. (C) Activin A knockdown augmented the adhesion to coated-surfaces, as revealed by significantly higher adhesion of shINHBA cells compared with shControl cells. (D) Activin A induced significantly the migration of HaCat cells, whereas follistatin blocked it and also reduced significantly the invasion of SCC-9 ZsGreen LN-1 cells through Matrigel-covered surfaces (E). (F) The migration and invasion of shINHBA cells were significantly lower in comparison with shControl cells. (G) Knock down of activin A interferes with cytoskeleton organization, reducing filopodia and lamellipodia formation. The number of filopodia and lamellipodia was significantly lower in shINHBA cells than in shControl cells. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.