Fig 4. Analysis of coupled signaling pathways.

A: Sensitivity profile: maximum of the derivative of each state variable w.r.t. each of the parameters ($\frac{d{x}_i}{d{p}_j},i=1,\dots ,n_x,j=1,\dots ,n_p$) for all simulated time points and for all 500 state variables. B: Estimated maximal absolute error for the adaptive interpolation for all 500 state variables with respect to the number of ODE solves in the region p ₀ ± 0.01p ₀. Error curves for adaptively expanded regions show a similar trend (see S1 Text).