Table 2.

Association between FGF23 and Carotid Plaque Presence and TCPA^*

	FGF23 level	Model 1		Model 2		Model 3
		OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Plaque presence	per lnFGF23	1.26 (1.04, 1.52)	0.02	1.26 (1.02, 1.56)	0.03	1.26 (1.01, 1.58)	0.04
	Quintile 1	Reference		Reference		Reference
	Quintile 2	0.94 (0.68, 1.30)	0.71	0.96 (0.68, 1.35)	0.82	0.94 (0.66, 1.34)	0.73
	Quintile 3	1.14 (0.83, 1.57)	0.42	1.27 (0.89, 1.80)	0.19	1.16 (0.81, 1.67)	0.41
	Quintile 4	1.22 (0.89, 1.69)	0.22	1.33 (0.93, 1.90)	0.12	1.24 (0.86, 1.79)	0.28
	Quintile 5	1.56 (1.13, 2.17)	0.007	1.57 (1.09, 2.26)	0.02	1.49 (1.02, 2.19)	0.04
		p for trend = 0.002		p for trend = 0.003		p for trend = 0.01

		Beta (95% CI)	P	Beta (95% CI)	P	Beta (95% CI)	P
TCPA	per lnFGF23	0.21 (0.08, 0.33)	0.001	0.20 (0.08, 0.32)	0.001	0.19 (0.07, 0.31)	0.002
	Quintile 1	Reference		Reference		Reference
	Quintile 2	−0.06 (−0.28, 0.16)	0.61	−0.02 (−0.22, 0.19)	0.89	−0.02 (−0.23, 0.17)	0.77
	Quintile 3	0.10 (−0.12, 0.31)	0.39	0.18 (−0.02, 0.39)	0.08	0.12 (−0.08, 0.32)	0.24
	Quintile 4	0.14 (−0.08, 0.36)	0.20	0.22 (0.01, 0.43)	0.04	0.15 (−0.05, 0.36)	0.15
	Quintile 5	0.38 (0.17, 0.60)	0.0006	0.38 (0.17, 0.60)	0.0005	0.32 (0.10, 0.53)	0.004
		p for trend = 0.0001		p for trend <.0001		p for trend = 0.0007

Model 1: unadjusted

Model 2: adjusted for age, sex, race/ethnicity, eGFR, and time interval between FGF23 and carotid examination.

Model 3: adjusted for age, sex, race/ethnicity, eGFR, and time interval between FGF23 and carotid examination plus vascular risk factors.

^*TCPA: Total Carotid Plaque Area (cube root transformed)