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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Jun 25;35(9):1936–1944. doi: 10.1161/ATVBAHA.115.305348

Figure 3. Effects of MC3/4 antagonism on the actions of α-MSH and [D-TRP8]-γ-MSH.

Figure 3

Leukocyte recruitment in the cerebral microcirculation was quantified in terms of: rolling cell flux and adhesion (cells/mm2/min), following BCCAo and 40min or 2h reperfusion. Affect of the MC3/4 antagonist SHU9119 when administered 10μg i.p at the start of reperfusion on A) leukocyte rolling cell flux and B) leukocyte adhesion. Leukocyte rolling C) and adhesion D) was also assessed in mice treated with either α-MSH or [D-TRP8]-γ-MSH alone (10μg) or in combination with SHU9119 (10μg). α-MSH 40min co-treatment group n=6 mice/group all other co-treatment groups n=4. Comparisons were made to singular treatment groups from Figure 2. Statistical analysis was performed comparing different treatments within the same time of reperfusion. † represents statistical significance to saline treated BCCAo group P<0.01. †† = P<0.001