Table 2.
Histological Evaluation
| Rabbit # | Length of Implantation |
Embedding Material |
Clinical Observations |
Keratocyte Hyperactivity |
Polymorphonuclear Cells |
Epithelial Thinning |
Myofibroblasts (IHC) |
Macrophages (IHC) |
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | GMA | Clear cornea | In stroma underneath the implant | None | Yes | - | - |
| 2 | 2 | GMA | Clear cornea | No | None | No | - | - |
| 3 | 2 | GMA | Clear cornea | No | None | No | - | - |
| 4 | 2 | GMA | Diffuse haze | No | None | Yes | - | - |
| 5 | 2 | Paraffin | Diffuse haze | No | None | No | None | None |
| 6 | 2 | Paraffin | Diffuse haze | Posterior to implant | None | Yes | None | None |
| 7 | 6 | Paraffin | Clear cornea | No | None | No | None | Yes |
| 8 | 6 | Paraffin | Inflammation, opacity, neovascularization, epithelial defect | Throughout the anterior cornea | Yes | Yes | At the peripheral cornea | Yes |
| 9 | 9 | GMA | Corneal thinning and extrusion | No | None | No | - | - |
| 10 | 9 | Paraffin | Epithelial defect | Posterior to implant | Yes | Yes | Posterior to implant | Yes |
| 11 | 12 | GMA | Epithelial defect | In the anterior and posterior stroma | Yes | Yes | - | - |
| 12 | 16 | Paraffin | Corneal thinning, cellular infiltrate | No | None | No | None | Yes |
| 13-control | 2 | Paraffin | Clear cornea | No | None | No | None | None |