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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Nat Genet. 2015 Aug 10;47(9):1091–1098. doi: 10.1038/ng.3367

Figure 1. Mechanism tested by the PrediXcan method.

Figure 1

This figure shows the conceptual decomposition of the expression level of a gene into three components: genetically determined component, a component altered by the trait itself, and the remaining factors (including environment). PrediXcan estimates the genetically regulated component of expression (GReX) and correlates it with the trait to identify trait-associated genes.