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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Nat Genet. 2015 Jul 20;47(9):1011–1019. doi: 10.1038/ng.3356

Table 1.

Genes with significant burden of SSNVs

Gene Total SSNVs Q-value Recurrent Mutations Recurrent P-value SSNVs
TP53 7 7.3 × 10−9 – – p.S34X, p.S94X, p.T155N, p.R196X, p.A215V, p.I254T, p.R273P
CD28 4 3.3 × 10−4 p.F51V, p.Q77P 9.0 × 10−9 p.F51I, p.F51V, p.Q77P, p.K81N
RHOA 3 0.02 p.N117I 1.1 × 10−4 p.R70K, p.N117I, p.N117I
DNMT3A 4 0.06 – – p.P233L, p.Y584X, p.S669F, p.P777L
FAS 3 0.07 – – p.S212C, p.E261K, p.D265E
PLCG1* 4 0.14 p.S345F** 0.006 p.R48W, p.D342N, p.S345F, p.E1163K
*

Gene has a Q-value or false discovery rate between 0.1 and 0.25.

**

Same mutation found to be a recurrent, gain-of-function mutation in a prior report11