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. 2015 Aug 28;10(8):e0136428. doi: 10.1371/journal.pone.0136428

Table 3. Univariate analysis of L-asp-related hyperglycemia.

During entire treatment Induction phase Maintenance phase
Odds ratio 95% CI p-value Odds ratio 95% CI p-value Odds ratio 95% CI p-value
Age at onset (yrs)
1–4 vs 5–18 1.000 1.000 1.000
4.534 2.441–8.422 <0.0001 1.330 1.330–3.500 0.564 11.157 3.323–37.462 <0.0001
1–9 vs 10–18 1.000 1.000 1.000
5.442 3.308–8.953 <0.0001 3.731 1.424–9.778 0.0074 7.299 3.882–15.247 <0.0001
1–14 vs 15–18 1.000 1.000 1.000
3.656 1.455–9.183 0.006 7.629 2.082–27.954 0.002 1.685 0.493–5.759 0.405
Sex
female 1.000 1.000 1.000
male 0.824 0.506–1.340 0.4342 1.158 0.432–3.453 0.7065 0.519 0.281–0.957 0.0358
Risk
SR 1.000 1.000 - - -
HR 3.670 1.761–7.646 0.0005 0.628 0.217–2.630 0.6601 1.000
ER 4.735 1.974–11.361 0.0005 2.043 0.434–7.825 0.4069 1.001 0.449–2.234 0.9981
F 1.148 0.243–5.421 0.8620 - - - - - -
T 2.264 0.679–7.547 0.1833 1.667 0.330–8.415 0.5363 0.286 0.067–1.216 0.0902
BMI
< 22% 1.000 1.000 1.000
≥ 22% 4.713 2.064–10.761 0.0002 6.636 1.822–24.177 0.0041 6.716 2.385–18.913 0.0003
BMI percentile
< 85% 1.000 1.000 1.000
≥ 85% 2.042 1.147–3.637 0.0153 2.414 0.839–6.945 0.1021 1.931 0.953–3.911 0.0677
Obesity index
< 20% 1.000 1.000 1.000
≥20% 2.908 1.413–5.984 0.0037 3.315 0.930–11.823 0.0647 2.805 1.160–6.783 0.0221
Down syndrome
Absent 1.000 1.000 1.000
Present 3.286 1.086–9.946 0.0352 2.975 0.378–23.430 0.3005 3.853 0.755–19.671 0.1049

BMI, body mass index; CI, Confidence interval; ER, extremely high risk; F, induction failure; HR, high risk; SD, standard deviation; SR, standard risk; T, T-cell type.