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. 2015 Aug 28;10(8):e0136615. doi: 10.1371/journal.pone.0136615

Fig 4. Expression of μ-calpain but not other CCS genes is different in ALL blasts and nonmalignant BM B cells.

Fig 4

A. Significantly higher expression of CAPN1 (μ-calpain) gene in ALL blasts compared to control B cells. B,C. No differences between expression of CAPN2 (m-calpain) and CAST (calpastatin) genes in ALL blasts vs non-malignant B cells. Please mark huge variability of expression of both the CAPN1 and especially CAST genes. CCS gene expression is shown as proportion of the expression of GAPDH housekeeping gene considered 1. Box-and-whisker plots depict the means, SEM and SD respectively. P values (Kruskall-Wallis test) are given in the graphs; N(ALL) = 6, N(control) = 6. For the details see Materials and Methods.