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. 2015 Aug 28;10(8):e0136615. doi: 10.1371/journal.pone.0136615

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© 2015 Mikosik et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — A. Representative result of western blot determinantion of calpastatin and its immunoreactive fragments resulting from calpain activity in non-malignant BM CD19⁺ cells (lane 1), ALL blasts from a 12-year old patient (lane 2) and blasts from the same patient as in lane 2, but incubated in vitro for 24 hours with 4 μM calpain inhibitor IV (lane 3). Actin was used as a reference protein. For further details see Materials and Methods. B. Endogenous calpain activity in ALL blasts measured by degree of calpastatin degradation (loss of the native form) is significantly higher in the children more than 10 years old. Box-and-whisker plots depict the medians, 25^th and 75^th percentile and range respectively. Asterisk signifies p = 0.01; N (1–10 years old ALL patients) = 27, N(>10 years old ALL patients) = 10.