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. 2015 Aug 28;10(8):e0136692. doi: 10.1371/journal.pone.0136692

Table 1. Comparative analysis of biochemical parameters of various cyclophilins.

Organism Generic name Catalytic efficiency Kcat/Km (M-1 s-1) Single domain (SD)/ Multidomain (MD) Inhibition constant (ki) for CsA (nM) References
Arabidopsis thaliana AtCyp19-3 2.7x106 SD 18.75 This study
Ricinus communis RcCyp1 9.48x106 SD - Gottschalk et al., 2008 [16]
Oryza sativa OsCyp2 4.5 x106 SD - Kumari et al., 2009 [23]
Arabidopsis thaliana AtCyp22 5.7 x106 SD 8.0 Grebe et al., 2000 [28]
Triticum aestivum TaCypA-1 2.32x105 SD 78.3 Sekhon et al., 2013 [29]
Zea mays ZmCyp18 11x106 SD 6.0 Sheldon and Venis, 1996 [30]
Citrus sinensis CsCyp 5.6x106 SD - Campos et al., 2013 [31]
Spinacia oleracea TLP40 1.6x106 MD - Fulgosi et al., 1998 [32]
Homosapiens Cyp40 1.9x106 MD 2–200 Kieffer et al., 1992 [33]
Kofron et al., 1991 [34]
Homosapiens CypA 1.4 x 107 SD 2.9 Daum et al., 2009 [35]
Homosapiens CypB 5.6 x 106 SD 8.4 Daum et al., 2009 [35]