Table 1. Comparative analysis of biochemical parameters of various cyclophilins.
Organism | Generic name | Catalytic efficiency Kcat/Km (M-1 s-1) | Single domain (SD)/ Multidomain (MD) | Inhibition constant (ki) for CsA (nM) | References | |
---|---|---|---|---|---|---|
Arabidopsis thaliana | AtCyp19-3 | 2.7x106 | SD | 18.75 | This study | |
Ricinus communis | RcCyp1 | 9.48x106 | SD | - | Gottschalk et al., 2008 | [16] |
Oryza sativa | OsCyp2 | 4.5 x106 | SD | - | Kumari et al., 2009 | [23] |
Arabidopsis thaliana | AtCyp22 | 5.7 x106 | SD | 8.0 | Grebe et al., 2000 | [28] |
Triticum aestivum | TaCypA-1 | 2.32x105 | SD | 78.3 | Sekhon et al., 2013 | [29] |
Zea mays | ZmCyp18 | 11x106 | SD | 6.0 | Sheldon and Venis, 1996 | [30] |
Citrus sinensis | CsCyp | 5.6x106 | SD | - | Campos et al., 2013 | [31] |
Spinacia oleracea | TLP40 | 1.6x106 | MD | - | Fulgosi et al., 1998 | [32] |
Homosapiens | Cyp40 | 1.9x106 | MD | 2–200 | Kieffer et al., 1992 | [33] |
Kofron et al., 1991 | [34] | |||||
Homosapiens | CypA | 1.4 x 107 | SD | 2.9 | Daum et al., 2009 | [35] |
Homosapiens | CypB | 5.6 x 106 | SD | 8.4 | Daum et al., 2009 | [35] |