Table 3. Upstream regulators.
Transcription regulators, recognized to be upstream regulators (z-score +-2), with actual fold change, z-score, p-value of overlap and number of downstream effectors.
| IPA ID | Entrez Gene Name | FC | Z-score | p-value of overlap | # of DTM |
|---|---|---|---|---|---|
| Activated upstream transcription factors | |||||
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 4.796 | 3.80x10-13 | 76 | |
| CREB1 | cAMP responsive element binding protein 1 | 3.661 | 5.10x10-8 | 79 | |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A | 2.998 | 1.25x10-5 | 49 | |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 2.952 | 2.15x10-3 | 29 | |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 2.808 | 1.67x10-5 | 33 | |
| ATF4 | Activating transcription factor 4 | 2.637 | 2.490 | 1.59x10-14 | 38 |
| SMAD2 | SMAD family member 2 | 2.425 | 1.00 | 6 | |
| KDM5B | lysine (K)-specific demethylase 5B | 2.400 | 4.19x10-4 | 21 | |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 3.143 | 2.359 | 1.59x10-12 | 136 |
| HMGB1 | high mobility group box 1 | 2.303 | 6.46x10-2 | 10 | |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 2.170 | 1.00x10-2 | 5 | |
| EHF | ets homologous factor | 2.121 | 1.35x10-1 | 9 | |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | 2.000 | 7.58x10-3 | 5 | |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 2.000 | 9.41x10-3 | 4 | |
| Inhibited upstream transcription factors | |||||
| TWIST1 | twist family bHLH transcription factor 1 | -3.182 | 8.83x10-8 | 32 | |
| GATA2 | GATA binding protein 2 | -2.724 | 3.03x10-6 | 19 | |
| KLF2 | Kruppel-like factor 2 | -2.396 | 1.42x10-6 | 28 | |
| PRDM1 | PR domain containing 1, with ZNF domain | -2.255 | 5.26x10-3 | 17 | |
| NEUROG3 | neurogenin 3 | -2.219 | 1.00 | 5 | |
| HOXA7 | homeobox A7 | -2.200 | 8.52x10-2 | 5 | |
| HOXA9 | homeobox A9 | -2.183 | 1.74x10-1 | 18 | |
| PLAG1 | pleiomorphic adenoma gene 1 | -2.164 | 4.62x10-3 | 11 | |
| GLI2 | GLI family zinc finger 2 | -2.159 | 6.27x10-2 | 11 | |
| NEUROG1 | neurogenin 1 | -2.111 | 1.63x10-2 | 11 | |
DTM: dysregulated target molecules