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. 2015 Aug 28;10(8):e0135466. doi: 10.1371/journal.pone.0135466

Table 1. Summary of studies on the cost-effectiveness of rapid onsite evaluation (ROSE).

Study FNAB Procedure Setting Results and Conclusion
Bruno, 2013[28] Transbronchial needle aspiration Italy ROSE reduced costs by 19,400 euros over 60 cases (about $367 per case) by reducing the frequency of medianoscopy
Burgess, 2013[31] Ultrasound guided,Head and neck,(thyroid, salivary glands, lymph nodes) United Kingdom ROSE would save approximately $164 per case if ROSE increased the adequacy rate to 100%.
Eedes, 2004[7] Thyroid USA, academic center ROSE increased the diagnostic rate at a cost of 220 minutes per diagnostic sample. ROSE is only likely to be cost-effective in limited situations such as for repeat procedures.
Layfield, 2001[9] Wide range of procedures: both image and palpation guided. USA, academic center. Cost of pathologist time to perform ROSE exceeds compensation by about $45 for image guided procedures. Compensation may be adequate only when samples are taken and immediately interpreted by the pathologist.
Nasuti, 2002[8] 5688 cases covering a wide range of anatomic sites USA, academic center. ROSE saved about $356 per case based on a total cost of $3096 per case.
Urquiza, 2007[32] Endoscopic ultrasound guided FNA for gastro-intestinal lesions Spain Cost of sampling was $47 per correct diagnosis with ROSE and $49.5 per correct diagnosis without. ROSE was cost effective
Zanocco, 2013[10] US guided thyroid USA, academic center The cost per quality adjusted life year was approximately $639,000 per case. ROSE is not cost effective.